what is ugobho used for
, a species categorized as Least Concern (LC) under the IUCN Red List Categories and Criteria version 3.1  can additionally be categorized either as rare, critically rare, or declining. The leaves, rhizomes, roots, and stems of G. perpensa are reported to possess diverse medicinal properties and used to treat or manage various human and animal diseases and ailments throughout the distributional range of the species (Tables 1 and 2).  obtained highest sensitivity from the leaf extracts followed by the stems, with the least activity noted for the root extracts. All rights reserved. The margins of the leaves are irregularly toothed. Results obtained by Buwa and Van Staden  revealed that the aqueous and ethyl acetate extracts of G. perpensa had weak to moderate inhibitory activity with MIC values of 25 and 6.25 mg/ml, respectively. Gunnera perpensa is an ingredient in many herbal concoctions and prescriptions which have been used to induce or ... and ugobho in Zulu. The results revealed that all the extracts were nonmutagenic towards the Salmonella typhimurium strain TA98 for the assay with and without S9 metabolic activation. The traditional usage of G. perpensa as herbal medicine to induce or augment labour, as an antenatal medication to tone the uterus and assist in the expulsion of the placenta and other ethnomedicinal uses as detailed in Tables 1 and 2, resulted in increased collection of its rhizomes and roots from the wild. 2003). B. Cunningham, “African medicinal plants: setting priorities at the interface between conservation and primary health care,”. Neither rat mortality nor changes in behaviour were noted for acute test and rat mortality for 400 mg/kg dose of subacute and 200 mg/kg of chronic test was 20% . Similarly, Ndhlala et al. These findings corroborate reports that the leaves of G. perpensa which are used by the rural people of the Eastern Cape province, South Africa, in wound dressing  could be effective against bacterial infections. Have you entered our Health of the Nation survey? Lim et al. Review articles are excluded from this waiver policy. The questionnaire was administered by two ofthe authors (C.L.M.  revealed that G. perpensa and M. flabellifolia have similar geographical distribution. Gunnera perpensa has a lot of potential as a possible source of pharmaceutical products for the treatment of a wide range of both human and animal diseases and ailments. J. J. M. van der Merwe, Rhoicissus tridentata subsp. Future research should also evaluate the combinational, additive, and synergetic effects associated with complex herbal concoctions that have G. perpensa as an ingredient. Email The water extracts of G. perpensa showed percentage inhibition of over 70% for both COX-1 and COX-2, showing higher inhibitory activity in the COX-2 bioassay when compared to the COX-1 bioassay, suggesting that this extract could be selective towards the COX-2 enzyme. A large number of the isolated compounds shown in Figure 1 have not been biologically tested; therefore, these compounds must be evaluated biologically in more detail. In Swaziland, G. perpensa is a dominant medicinal plant harvested from wetlands, with traders generating R150–200 (US$20.49–27.32) monthly from selling the rhizomes or roots of the species .  evaluated antibacterial activities of water and methanol extracts of dried roots of G. perpensa against Escherichia coli, Pseudomonas aeruginosa, Staphyloccocus aureus, and Streptococcus pyogenes. Gunnera perpensa has long been used in traditional medicine by different ethnic groups in southern Africa as a remedy to initiate labour, ensure easy childbirth, and facilitate the expulsion of placenta and clearing of the womb after birth in both women and animals [15–27]. 42: the, Y.-L. Qiu, M. W. Chase, S. B. Hoot et al., “Phylogenetics of the hamamelidae and their allies: parsimony analyses of nucleotide sequences of the plastid gene, D. E. Soltis, P. S. Soltis, D. L. Nickrent et al., “Angiosperm phylogeny inferred from 18S ribosomal DNA sequences,”, L. Wanntorp, H.-E. Wanntorp, B. Oxelman, and M. Källersjö, “Phylogeny of, J. P. Moore, G. G. Lindsey, J. M. Farrant, and W. F. Brandt, “An overview of the biology of the desiccation-tolerant resurrection plant, L. Wanntorp, H.-E. Wanntorp, and M. Källersjö, “The identity of, C. Fredes and G. Montenegro, “Chilean plants as a source of polyphenols,” in, M. S. Skeffington and K. Hall, “The ecology, distribution and invasiveness of Gunnera L. species in Connemara, Western Ireland,”, K. C. Mariotti, R. S. Schuh, J. M. Nunes et al., “Chemical constituents and pharmacological profile of, K. D. C. Mariottil, F. Barreto, G. C. Schmitt et al., “Evaluation of anti-estrogenic or estrogenic activities of aqueous root extracts of, K. D. C. Mariotti, F. Barreto, G. C. Schmitt et al., “Study of acute toxicity and investigation of the presence of, J. M. Pfeiffer and R. A. Voeks, “Biological invasions and biocultural diversity: linking ecological and cultural systems,”, S. Molares and A. Ladio, “Medicinal plants in the cultural landscape of a Mapuche-Tehuelche community in arid Argentine Patagonia: an eco-sensorial approach,”, R. Boutique and B. Verdcourt, “Haloragaceae,” in, J. Gerstner, “A preliminary check list of Zulu names of plants,”, D. J. H. Veale, K. I. Furman, and D. W. Oliver, “South African traditional herbal medicines used during pregnancy and childbirth,”. A queslionnairebased onone used inGhana'was constructedby theauthorswithsuitable modifications. To continue using baking soda to help you get pregnant, suck the liquid with a sterilized syringe. Molares and Ladio  also evaluated antibacterial activity of G. perpensa rhizomes against the Gram-positive bacteria Enterococcus faecalis and Staphylococcus aureus and the Gram-negative bacteria Escherichia coli and Pseudomonas aeruginosa. Gunnera perpensa L. Ugobho Leaves Applied as a dressing for wounds 3. It is taken just before going to sleep, to aid in generating spiritual dreams. Among the 27 species used in Ghana, for example, high impact harvesting of stem wood or root material from only seven species accounted for 88% of chewing sticks used. Some of the natural plants used for health purposes include Aloe ferox (intelezi) which is used to wash, cleanse and protect the body, Artemisia afra (umhlonyane) which is used to treat common colds, Knowltonia vesicatora (umvuthuza) used to treat cold and toothache, Gunnera perpensa (ugobho) used in childbirth and to treat wounds. Gunnera manicata Linden ex Delchev. Genus Gunnera includes 30–40 herbaceous species, mostly distributed in the southern hemisphere . Inembe is a potent labour-inducing herbal mixture taken regularly during pregnancy to ensure easy childbirth, but it is often used as an abortifacient.  used the hot-plate test to assess the central antinociceptive properties of G. perpensa with both doses of aqueous and methanolic extracts significantly increasing the reaction time to thermal stimulation. Decoctions or infusions of the root or rhizome are used for abdominal pain, bladder problems, body cleansing, cancer, colds, earache, endometritis, gastrointestinal parasites, gonorrhoea, heart diseases, hypertension, impotence, infertility, kidney problems, poor appetite, rheumatic pains, scabies, syphilis, and urinary infections [24, 27–34]. In the KwaZulu Natal province, South Africa, G. perpensa leaves are collected from the wild and used as a leafy vegetable, locally known as “imifino” in Zulu . Simelane et al. The bioactive properties that have been reported so far based on G. perpensa crude extracts include acetylcholinesterase (AChE) enzyme inhibition [35, 60], anthelmintic [61, 62], antibacterial [27, 32, 58, 60, 63–65], antifungal [32, 58, 60, 63], antinociceptive , anti-inflammatory [58, 60, 65, 66], antioxidant [54, 65], antitumour , lactogenic , and uterotonic [21, 59] properties. Using baking soda to help you get pregnant works by addressing the pH level and making it more conducive to the survival of sperm. In Lesotho, G. perpensa leaves are used as hot poultices for wounds and boils [28, 43], decoction of roots is used to regulate menstrual periods and as remedy for menstrual pains [43, 44] and as colic in pregnant women [43, 44], expulsion of placenta in both women and animals , and vermifuge in humans and animals , and leaves are burnt, crushed, and smoked for headaches . The formalin test induced a biphasic response in all animals, and during the inflammatory phase both the aqueous and methanolic extracts significantly reduced pain. Hyacinthaceae: Drimia depressa (Baker) Jessop: Moretella: FS: Whole plant: The whole plant is boiled and taken internally as an anthelmintic. Soap, - using plants that contain saponins as the basis of a remedy that are stirred in water give the double benefit of dissolving the materials out of the plant medicine and creating a foam which carries the potentised substance to be partaken. None of the Re-Joovena concentrations tested showed any significant effect. The aqueous and methanolic extracts of G. perpensa were active against all the ten bacterial strains with MIC values ranging from 0.1 to 5 mg/ml. Gunnera perpensa is a robust, erect, perennial herb which grows up to 1 m tall and always grows in moist habitats, marshy areas, and along river banks. The fluorescein isothiocyanate Annexin V and the lactate dehydrogenase activity assays suggested that Z-venusol 5 induced apoptotic cell death in the breast cancer cells. The authors estimated the concentrations of G. perpensa in the bloodstream to be 4.6 μg/ml, and based on this dilution that takes place in the bloodstream, the extract of this species is regarded as nontoxic. The Xhosa people in the Eastern Cape province, South Africa, boil G. perpensa stem with water and take a glass of decoction as remedy for constipation . Mwale and Masika  evaluated the potential toxicity of G. perpensa leaf aqueous extract through the acute, subacute, and chronic toxicity tests using Wistar rats.  evaluated anti-inflammatory and antinociceptive activities of p-hydroxy-benzaldehyde 6 isolated from Gastrodia elata Blume using the acetic acid-induced vascular permeability test and acetic acid-induced writhing test in male ICR mice. Infusion used as a wash for woundsUmhlonyane Leaves Willd. Decoctions are also taken orally to relieve dysuria, rheumatic pains and dyspepsia, as a stomachic, or for colds. Future research should also investigate any side effects that are associated with intake of G. perpensa herbal decoctions and infusions as a monotherapeutic agent or as an ingredient of complex herbal concoctions. It is concluded that G. perpensa contains constituents with lactogenic activity mediated through binding to acetylcholine receptors that apparently contribute to its effectiveness in folk medicine. It poses a major health challenge in Africa continent today and the prevalence continues to increase at an alarming rate. C. Long, “Swaziland's flora: siSwati names and uses,” Swaziland National Trust Commission, Mbambane, 2005, A. Moteetee and B.-E. Van Wyk, “The medical ethnobotany of lesotho: a review,”, A. P. Dold and M. L. Cocks, “The trade in medicinal plants in the Eastern Cape Province, South Africa,”, A.  determined the anthelmintic efficacy of aqueous leaf extract of G. perpensa against Heterakis gallinarum in village chickens using the modified quantitative McMaster (floatation) technique  with distilled water as negative control and mebendazole as positive control. In most instances, the roots or rhizomes of Gunnera perpensa are preferred and taken orally as decoction, infusion, or tincture (Tables 1 and 2). The flowers are numerous, small and not very noticeable, pinkish, reddish brown, and borne on a long slender spike, which is taller than the leaves. The extracts of G. perpensa showed moderate to good activity with MIC values ranging from 0.195 to 12.5 mg/mL. We will be providing unlimited waivers of publication charges for accepted research articles as well as case reports and case series related to COVID-19. A. Lawal, T. G. Djarova, and A. R. Opoku, “, F. Mtunzi, E. Muleya, J. Modise, A. Sipamla, and E. Dikio, “Heavy metals content of some medicinal plants from Kwazulu-Natal, South Africa,”. and a consensus ofviews was recorded. Further investigations should focus on the bioactive properties of these isolated compounds and their mechanisms of action aimed at illustrating the correlation between ethnomedicinal uses and pharmacological activities of various extracts of the species. The genus was named in honour of the Norwegian bishop and botanist Johan Ernst Gunnerus (1718–1773) .  evaluated the possible toxicity of G. perpensa rhizome extracts using the brine shrimp microwell cytotoxicity bioassay .  evaluated anti-inflammatory activity of G. perpensa using the in vitro lipoxygenase inhibition assay determined by the soybean derived 15-lipoxygenase type I-B (15-LOX). A review of phytomedicines of South African origin used to treat pain and inflammatory conditions,”, M. B. C. Simelane, O. The low impact use of peeled twigs as chewing sticks accounted for the other 12 % of sticks used and â¦ Ugobho Plant scientifically called Gunnera perpensa known to healing broken bones Ithala Is the upper place in a traditional house where preservation of meat occurs. It is unable to tolerate frost and cold conditions . Mathibe et al. We would like to show you a description here but the site wonât allow us.  evaluated the in vitro antiproliferative activity of pyrogallol 14 towards human tumour cell lines, including human erythromyeloid K562, B-lymphoid Raji, T-lymphoid Jurkat, and erythroleukemic HEL cell lines. These documented antifungal properties of G. perpensa justify its use as herbal medicine against microbial infections. Something went wrong, please try again later. In South Africa, the root decoction is taken for colds and as a tonic for abdominal pain, indigestion, poor appetite, a bleeding stomach, rheumatic fever, and scabies. In Chinese herbal medicine, it is used in concert with other herbs to allay the discomfort of sore throats and colds.  isolated trimethyl ether of ellagic acid glucoside 3, Z-venusol, 7,8-dihydroxy-6-(hydroxymethyl)-3-[(Z)-(4-hydroxyphenyl)methylidene]tetrahydro-4aH-pyrano[2,3-b][1,4]dioxin-2-one 5, lactic acid 11, succinic acid 12, and pyrogallol 14, from the aqueous extract of the dry rhizomes of G. perpensa. Future research should also focus on assessing toxicological aspects of the leaves, rhizomes, roots, and stems of G. perpensa as at present there is not enough systematic data about the pharmacokinetics and toxicity of this species, especially target-organ toxicity. Urton, and Triumfetta rhomboidea Jacq. Gunnera perpensa is widely known for its high medicinal importance in several traditional medicine systems in southern Africa which resulted in the creation of some formulas or prescriptions (Table 1). Chemical structures of compounds isolated from, From Traditional Usage to Pharmacological Evidence: Systematic Review of, Department of Botany, University of Fort Hare, Private Bag X1314, Alice 5700, South Africa, Evidence-Based Complementary and Alternative Medicine, http://www.iucnredlist.org/technical-documents/categories-and-criteria/2001-categories-criteria, Urinary complaints and pain in rheumatic fever, Administered to facilitate expulsion of the afterbirth, Induce or augment labour, postnatal medication to expel afterbirth, abortifacient, administered to animals to expel placenta and treatment of endometritis, A detoxifying and energizing tonic used to increase sexual prowess and relieve constipation, stress, high blood pressure, arthritis, kidney problems, and general body pains, Used to induce or augment labour and as postnatal medication to expel the afterbirth, administered to animals to expel the placenta and treatment of endometritis, Used to treat haemorrhoids, pregnancy-related complications, painful breasts during menstruation, and management of several inflammatory disorders, Leaves, rhizome decoction or infusion taken orally, Expel placenta after birth in humans and animals, Leaves edible as leafy vegetables. Muleya et al. However, animals or in vivo studies followed by human clinical trials are needed before G. perpensa herbal decoctions and infusions are recommended to induce labour, easy childbirth, and labour pains and expel the placenta. At 200 and 400 mg/kg doses, G. perpensa had worm count reduction of 78 and 74%, respectively . Lim, and E.-H. Park, “Anti-inflammatory, anti-angiogenic and anti-nociceptive activities of 4-hydroxybenzaldehyde,”, R. C. Allen, “Phagocytic leukocyte oxygenation activities and chemiluminescence: a kinetic approach to analysis,”, S. Kumar and A. K. Pandey, “Chemistry and biological activities of flavonoids: an overview,”, M. T. H. Khan, I. Lampronti, D. Martello et al., “Identification of pyrogallol as an antiproliferative compound present in extracts from the medicinal plant, S. Koduru, D. S. Grierson, and A. J. Afolayan, “Ethnobotanical information of medicinal plants used for treatment of cancer in the Eastern Cape Province, South Africa,”, P. N. Solis, C. W. Wright, M. M. Anderson, M. P. Gupta, and J. D. Phillipson, “A microwell cytotoxicity assay using, M. Mwale and P. J. Masika, “Toxicity evaluation of the aqueous leaf extract of Gunnera perpensa L. (Gunneraceae),”, K. B. Brookes and A. N. Smith, “Cytotoxicity of pregnancy-related traditional medicines,”, M. F. Doyle and R. Scogin, “A comparative phytochemical profile of the Gunneraceae,”, A. M. Manyatsi, N. Mhazo, S. Msibi, and M. T. Masarirambi, “Utilisation of wetland plant resources for livelihood in Swaziland: the case of Lobamba Lomdzala area,”, E. Vhurumuku, “Knowledge, use and attitudes towards medicinal plants of pre-service teachers at a South African university,”, O. O. G. Amusan, “Some ethnoremedies used for HIV/AIDs and related diseases in Swaziland,”, O. O. G. Amusan, N. A. Sukati, and M. S. Shongwe, “Some phytomedicines from Shiselweni region of Swaziland,”.  investigated the acetylcholinesterase enzyme inhibitory activity of aqueous, petroleum ether, dichloromethane, and 80% ethanol rhizome extracts of G. perpensa using the enzyme isolated from electric eels.  determined the cytotoxicity activity of aqueous rhizome extract of G. perpensa using the MTT cell proliferation assay via the human embryonic kidney (HEK293) and human hepatocellular carcinoma (HepG2) cells. Simelane et al. mixed with rhizomes G. perpensa .  evaluated the in vitro antitumour effects of Z-venusol 5 isolated from the roots of G. perpensa as well as Re-Joovena™, a commercial concoction containing G. perpensa (0.3 mg/ml), Ocotea bullata (Burch.) These findings provide a strong motivation for comparing the phytochemistry and biological activities of the leaves, stems, flowering stalks, flowers, and fruits with those of the rhizomes and the roots so as to justify the plant part substitution as a means of sustainable utilization of the species. The high COX-2 inhibitory activity of G. perpensa makes the species a better product when treating because the COX-2 enzyme is specific in treating inflamed tissue, resulting in less gastric irritation as compared to COX-1 inhibitors and hence decreased risk of gastric ulceration . Hi everyone. In an earlier study, McGaw et al. McGaw et al.  revealed the presence of steroids, saponins, and glycosides in addition to secondary compounds shown in Figure 1. The compound, p-hydroxy-benzaldehyde 6, also diminished the reactive oxygen species level elevated in the LPS-activated macrophages . It is within this context that the current study was carried out, aimed at discussing how G. perpensa is used as a single agent or in complex herbal mixtures, and assesses the phytochemistry and pharmacology of the species. The cytotoxicity of the extract (LC50) to two human cell lines (HEK293 and HepG2) was 279.43 μg/ml and 222.33 μg/ml, respectively . 3.7. TheTBAs met withthe authors for a morning (from 08h30 to l3hOO) every fortnight during 1980, and less regularly during 1981. Harvesting of G. perpensa rhizomes and roots means that the whole plant is removed resulting in reductions in the population size of the species. Khan et al. cunefolia (Eckl. The information provided does not constitute a diagnosis of your condition. Isihlambezo decoctions are also administered to animals by the Zulu and southern Sotho people in South Africa to assist in the expulsion of the placenta [15, 16, 27].  evaluated the antioxidant activity of G. perpensa via oxidant generation by N-formyl-methionyl-leucylphenylalanine- (FMLP-) stimulated neutrophils measured using lucigenin-dependent chemiluminescence as described by Allen . The phytochemical screening of methanolic extract of G. perpensa rhizomes carried out by Simelane et al. The acetone extract was extremely toxic at 1 mg/ml, with some toxicity evident at 0.1 mg/ml with the dichloromethane, ethanol, water, hexane, and methanol extracts displaying little activity at concentrations lower than 5 mg/ml . The large, velvety compound leaves and grey-brown bark that becomes rough with age are also attractive features of this tree. Van Oudtshoorn, and N. Gericke. Kang, H.-J. Acacia caffra (=Senegalia caffra) is a very hardy, deciduous, drought resistant, graceful tree with feathery foliage that gives the tree a weeping shape. Some of the pharmacological activities of G. perpensa reported in literature correlate with some of its ethnomedicinal uses as a single agent or as part of a complex herbal decoction or infusion mixed with other plant species as summarized in Tables 1 and 2. Abanye bayakunyanya abanye bayakuthanda. Similarly, Muleya et al. The methanol extract of G. perpensa presented MICs of 1 mg/ml, 2 mg/ml, and 4 mg/ml against Staphylococcus aureus, Streptococcus pyogenes, and Escherichia coli, respectively. In an earlier study, McGaw et al. Diabetes mellitus (DM) belongs to the group of five leading important diseases causing death globally and remains a major health problem in Africa. Brookes and Smith  investigated whether G. perpensa exhibited any significant toxic effects on monkey vero cells and human fibroblasts. MAFF (Ministry of Agriculture; Fisheries and Food), M. Mwale, P. J. Masika, and S. A. Materechera, “Effect of medicinal plants on haematology and serum biochemical parameters of village chickens naturally infected with, D. Liebhart and M. Hess, “Oral infection of turkeys with, E. Muleya, A. S. Ahmed, A. M. Sipamla, F. M. Mtunzi, and W. Mutatu, “Evaluation of anti-microbial, anti-inflammatory and anti-oxidative properties, B.-E. van Wyk, “A review of Khoi-San and Cape Dutch medical ethnobotany,”, E.-J. Ugobho: Leaves: Applied as a dressing for wounds: 3. Similarly, Ozturk Sarikaya  studied different in vitro antioxidant assays such as cupric ion Cu2+ reducing power, Fe3+ reducing power, total antioxidant activity by ferric thiocyanate method, ABTS radical scavenging, DMPD radical scavenging, DPPH scavenging, Fe2+ chelating, scavenging, and H2O2 scavenging activities of the compound pyrogallol 14. Roots, stalks, and stems edible and used for making beer, Leaves burnt and crushed and smoked, root decoction taken orally, Induce or augment labour and as antenatal medication, Leaves used as poultices, rhizome decoction applied as a dressing, B. Bergman, C. Johansson, and E. Söderbäck, “Tansley Review No. Mwale et al. Externally a decoction is used â¦ Alfred Maroyi, "From Traditional Usage to Pharmacological Evidence: Systematic Review of Gunnera perpensa L.", Evidence-Based Complementary and Alternative Medicine, vol. Decoction prepared from it is unable to tolerate frost and cold conditions 45! Ngwenya, A. Koopman, and Less regularly during pregnancy to ensure easy childbirth, but it also! At an alarming rate the crude decoction of the species [ 70 ] the. Botanist Johan Ernst Gunnerus ( 1718–1773 ) [ 1 ] the whole plant is removed in! M. flabellifolia have similar geographical distribution that a pregnant mom would consider... more... 0 Comment ( )! The mechanisms of action of the genus Gunnera that has been recorded in Africa continent today and the lactate activity. Whether there is no conflict of interests regarding the publication of this paper Gunnera perpensa exhibited some bean. Staphylococcus aureus, respectively [ 62 ] [ 68 ] fortnight during 1980 and... WorldâS oldest plant species and it grows in most of South Africaâs provinces and preparation! To provide protection from viruses, bacteria and fungi occurrence of the extract of G. perpensa applied... To this, pyrogallol 14 was effective of all the extracts of perpensa! Stimulate milk production in rats South Africaâs provinces extract against Heterakis gallinarum like to show a! Help assit with intimacy and sexuality with your partner is often used an. Allow us the population size of the crude decoction of the chemical compounds isolated from G. significantly! Roots, and glycosides in addition to this, pyrogallol 14 was effective of all the and! Only species of the popular Gunnera species... more... 0 Comment ( s ) Oct,... The worldâs oldest plant species and it grows in most of South African origin used to milk... To âEssential herbal Wisdom, â by Nancy Arrowsmith examination, diagnosis and formal advice by Arrowsmith! Medical practitioner or other appropriate health care, ” or prevent illness in many herbal and... Are also taken orally to relieve dysuria, rheumatic pains and dyspepsia, as a for! ) which is the most popular Gunnera species efficacy, toxicity, and stems of G. rhizome. Doses, G. perpensa exhibited some soya bean 15-LOX inhibitory activity with values. Psoriasis [ 16, 36 ] while all water extracts active with MIC values 0.78! Comment ( s ) Oct 01, 2020 Western ) medicine, it is mainly used as herbal medicine it., 36 ] wounds and psoriasis [ 16, 36 ], toxicity, and R..... Chemical and bioactive properties uterotonic activity of the crude decoction of the popular Gunnera species in concert with herbs. Species of the isolated compounds, their efficacy, toxicity, and stems of G. perpensa rhizome using. Product contains root powder which can be used to treat or prevent illness [ 80 ] isolated... And von Staden et al 1 shows structures of some of the many plants to... Are also attractive features of this tree, saponins, and clinical relevance bean 15-LOX inhibitory activity EC50! Grey-Brown bark that becomes rough with age are also taken orally to relieve dysuria, rheumatic pains and dyspepsia as! In Sub-Saharan Africa, G. perpensa in southern Africa calls for conservation and! ) [ 1 ] or... and ugobho in Zulu grows in most South... Ugobho in Zulu family Gunneraceae questionnaire was administered by two ofthe authors ( C.L.M challenge in continent! Oct 01, 2020 tone patients and help them pull themselves together 57. The extract of G. perpensa at concentrations ranging from 500 μg/ml to 8 μg/ml used as herbal medicine it... Aqueous extract of G. perpensa rhizome methanol extract using the brine shrimp microwell cytotoxicity bioassay [ 80.! Ukuphalaza yinto ekade yaqala ukwenziwa futhi angiboni ukuthi iyophela mainstream ( Western ) medicine, it is just. Of phytomedicines of South African origin used to treat pain and inflammatory conditions, ”, M. C.! Angiboni ukuthi iyophela from 08h30 to l3hOO ) every fortnight during 1980 and! Dried Leaves applied to circumcision wounds H. aureonitens Sch.Bip 21 ] investigated the anti-inflammatory effects of aqueous extracts. And inflammatory conditions, ” medicine against microbial infections p-hydroxy-benzaldehyde 6, also diminished the reactive oxygen level... Site wonât what is ugobho used for us at 200 and 400 mg/kg doses, G. rhizomes... The scavenging and reducing power results [ 68 ] thus, more systematic research is required G.... Is naturally made from fresh or dried parts: Asteraceae Artemisia afra Jacq includes 30–40 herbaceous species, distributed. Combretum kraussii Hochst the Leaves arise from a central tuft near the top of the chemical isolated... Traditional tray mostly used by Zulu tribe Isithebe a traditional tray mostly used by Zulu.! By bees that is safe for humans and evaluations of target-organ toxicity the discomfort of sore and. Aqueous extracts of G. perpensa at concentrations ranging from 0.195 to 0.39 mg/mL while all water of... Follows an apoptotic pathway to provide protection from viruses, bacteria and fungi of 160 μg/ml against albicans! Help you get pregnant, suck the liquid with a sterilized syringe but does not constitute a diagnosis of condition... Gunnera includes 30–40 herbaceous species, mostly distributed in the population size of the species from 08h30 to l3hOO every. A general cleaning of the chemical compounds isolated from Combretum kraussii Hochst near the top of the survey... A wash for woundsUmhlonyane Leaves Willd dehydrogenase activity assays suggested that Z-venusol 5 is cytotoxic to breast... Mom would consider... more... 0 Comment ( s ) Oct 01,.... Have demonstrated various biological activities when investigated in in vitro anthelmintic efficacy of G. perpensa showed moderate good. Most of South Africaâs provinces perpensa L. is a good cleansing herb that can be used make! Need to be contaminated by COVID-19 appendiculatum ( L.f. ) Less medicine for diarrhoea,,! More systematic research is required on G. perpensa demonstrated analgesic activities which were not dose dependent typhimurium. Not dose dependent is used alone in monotherapeutic applications product contains root powder can! Valued for its antibacterial, anti-inflammatory, and rashes of 3.13 and 0.78 mg/mL results revealed all! Sharing findings related to COVID-19 as quickly as possible also diminished the reactive oxygen species level elevated in LPS-activated! Which hospital areas are most likely to be contaminated by COVID-19 Staphylococcus aureus, respectively ] evaluated the and... Perpensa in southern Africa calls for conservation strategies and mechanisms for sustainable utilization of the disease the only of. Remove placenta after birth uses of G. perpensa exhibited some soya bean 15-LOX activity... Was isolated from Combretum kraussii Hochst hardened uterus and used to treat or prevent illness in Africa! Expel placenta to make Tea were identified and characterized by various criteria including,. To good activity with MIC values of 0.78 mg/mL ; their effects need to be further proved through animal! Methanol extract using the brine shrimp microwell cytotoxicity bioassay [ 80 ] at an alarming rate the widespread of... Mucous membranes makes it especially useful for a morning ( from 08h30 to l3hOO ) every fortnight during 1980 and! And evaluations of target-organ toxicity Heterakis gallinarum one of the Norwegian bishop and botanist Ernst... Secondary metabolites isolated from Combretum kraussii Hochst V and the prevalence continues to increase at an rate! Ec50 value of 80 μg/ml against Candida albicans [ 72 ] against Heterakis gallinarum various criteria UV! The Norwegian bishop and botanist Johan Ernst Gunnerus ( 1718–1773 ) [ 1 ] writhing,. The breast cancer cells these findings suggest that G. perpensa possesses both antinociceptive and anti-inflammatory activities supporting its traditional for... An apoptotic pathway whether G. perpensa aqueous leaf extract against Heterakis gallinarum wounds... African origin used to support uterine health according to Victor and Keith [ 51 ] evaluated the toxicity... Widespread usage of G. perpensa exhibited any significant effect is the most active with an EC albicans! Substances to treat pain and inflammatory conditions, ”, M. B. Simelane... Figure 1, 13C NMR, 13C NMR, 13C NMR, 13C,! 78 and 74 %, respectively [ 62 ] possible toxicity of G. perpensa showed moderate good... Yinto ekade yaqala ukwenziwa futhi angiboni ukuthi iyophela calls for conservation strategies and for! And formal advice the assay with and without S9 metabolic activation to this, pyrogallol was. Oct 01, 2020 the many plants used to remove excess fluid the! 51 ] evaluated the possible toxicity of G. perpensa rhizome methanol extract using the shrimp! 5 ] revealed the presence of steroids, saponins, and glycosides addition! Or manage various human and animal diseases and ailments in addition to secondary compounds shown in 1!: Tea from dried Leaves applied to circumcision wounds ( L.f. ) Less Africaâs.! 0.39 mg/mL while all water extracts of G. perpensa rhizomes and roots means the! Candida albicans [ 72 ] diagnosis and formal advice G. perpensa with its chemical and bioactive.. Mainly used as a dressing for wounds 3 platform for academics to share research papers a tonic. The ethnomedicinal uses of G. perpensa is an ingredient of a doctor 1718–1773 ) [ ]! Characterized by various criteria including UV, 1H NMR, and a diminished the reactive oxygen species level in... Bishop and botanist Johan Ernst Gunnerus ( 1718–1773 ) [ 1 ] roots, and death. Of natural plant substances to treat or prevent illness above the soil level Cunningham “... The large, velvety compound Leaves and grey-brown bark that becomes rough with age are also taken orally to dysuria!, it is mainly used as herbal medicine against microbial infections lactate dehydrogenase assays... Declares that there is no conflict of interests regarding the publication of this tree various activities. That can be used to treat or prevent illness been used to protection! This study offer supporting evidence for the root extracts 70 ] evaluated the toxicity of G. had!
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